Claudine Janet Diana Isaacs, MD| Cancer Genetics, Medical Oncology | MedStar Health
Claudine Janet Diana Isaacs

Claudine Janet Diana Isaacs, MD
Provider is directly employed by MedStar Health

4.9 out of 5 (498 reviews)

Specialties: Cancer Genetics, Medical Oncology, Breast Medical Oncology

Languages: English, French

202-444-9429

About me

Dr. Claudine Isaacs is a medical oncologist who specializes in the care of women with all stages of breast cancer. She is Professor of Medicine and Oncology, Associate Director of Clinical Research and Leader of the Clinical Breast Cancer Program at the Georgetown Lombardi Comprehensive Cancer Center. She is also the Medical Director of the Jess and Mildred Fisher Center for Hereditary Cancer and Clinical Genomics Research. She has been practicing for over 20 years.

Dr. Isaacs received her medical degree and internal medicine residency training at McGill University, Canada. She completed fellowship training in the Division of Hematology and Oncology at McGill University and a Fellowship in Breast Medical Oncology in the Division of Medical Oncology at Georgetown University. She then joined the faculty in the Department of Medicine and Oncology at Georgetown University.

Dr. Isaacs has extensive experience in the conduct of clinical trials focusing on all aspects of breast cancer. Additional research interests include cancer risk assessment and medical management and prevention strategies for women at high risk for breast cancer. She has served as the principal investigator of a variety of clinical trials in the treatment of early-stage and metastatic breast cancer, and currently serves as the principal investigator of the Translational Breast Cancer Research Consortium (TBCRC), the ISPY2 trial at Georgetown University. She has authored over 200 peer-reviewed publications. She has also served on a number of committees, including the Cancer Education Committee at the American Society of Clinical Oncology (ASCO), the ASCO Scientific Program Committee, the Breast Oncology Local Diseases Task Force of the Breast Steering Committee of the National Cancer Institute, and most recently the ASCO guidelines committee. She has been named one of America's Top Cancer Doctors by Castle Connolly/Newsweek for many years running, and has also received designations from Washingtonian Magazine and Women's Health Magazine.


Dr. Isaacs' Philosophy of Care:

I strive to personalize the care of my patients by tailoring state-of-the-art therapy to their individual situations and by providing them with access to cutting-edge clinical trials. Equally important is that the care of my patients extends well beyond focusing just on the optimal therapy of their cancer.  My approach to care is to relate to each of my patients as individuals in the context of their lives, and not solely based on the characteristics of their disease. To that end, I work with a wonderful and dedicated multidisciplinary group of expert colleagues who are deeply committed to and involved with our patients' care. The whole team is focused solely on breast cancer and includes medical oncologists, surgeons, radiation oncologists, breast imagers, and pathologists who are supported by an experienced team of clinical nurse coordinators, nurse navigators, research nurses, genetic counselors and social workers, all championing a multidisciplinary approach to breast cancer diagnosis, treatment and recovery. We are not treating a disease. We are treating a person and we are here to provide state-of-the-art medical treatment and to accompany that person navigates their cancer journey.

Clinical areas of focus

  • Breast Cancer
  • Cancer Genetics Consultation
  • Ductal Carcinoma In Situ (DCIS)
  • Family History-Based Cancer Risk Assessment
  • Genetic Mutation Testing
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Hereditary Cancer
  • Lobular Carcinoma In Situ (LCIS)
  • Papillary Carcinoma Of Breast
  • Transitional Cell Carcinoma
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Conditions and procedures

Conditions I treat

  • Breast Cancer
  • Breast Cancer Complications
  • Breast Cancer In Young Women
  • Breast Sarcoma
  • Ductal Carcinoma In Situ (DCIS)
  • Estrogen Receptor
  • Genetic Predisposition To Breast Cancer
  • Hodgkin Disease
  • Lobular Carcinoma In Situ (LCIS)
  • Papillary Carcinoma Of Breast
  • Transitional Cell Carcinoma
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Procedures I perform

  • A1c Testing
  • Abdominal Wall Biopsy
  • Adjuvant Hormone Therapy
  • Adrenal Antibody Testing
  • Antiangiogenic Therapy
  • Bladder Tumor Prevention
  • Bone Biopsy
  • Brca Gene Testing
  • Breast Biopsy
  • Breast Cancer
  • Breast Cancer And Fertility
  • Breast Cancer Chemoprevention
  • Breast Cancer Pain Management
  • Breast Cancer Screening
  • Breast Cancer Treatment
  • Breast Density Evaluation
  • Breast Infection Treatment
  • Breast Lift Surgery
  • Breast Seroma Aspiration
  • Ca 19-9 Test
  • Cancer Genetics Consultation
  • Cancer Risk Assessment
  • Cea Testing For Colorectal Cancer
  • Chemotherapy Administration
  • Circulating Tumor Cell Monitoring
  • Diagnostic Breast Imaging
  • Diagnostic Mammography
  • Digital Breast Tomosynthesis
  • Ductal Carcinoma In Situ (DCIS) Surgery
  • Family History-Based Cancer Risk Assessment
  • Fine Needle Aspiration Biopsy
  • Fish Testing For Breast Cancer
  • Genetic Counseling
  • Genetic Mutation Testing
  • Genetic Testing For Cancer Patients
  • Genetic Testing For Down Syndrome
  • Genetic Testing For Hereditary Cancer
  • Genetic Testing For Stargardt Disease
  • Genomic Testing For Cancer
  • High-Risk Breast Lesion Management
  • Hormone Replacement Therapy
  • Immunotherapy
  • Intra-Arterial Infusion Of Chemotherapy
  • Introduction Of Antineoplastic
  • Liquid Biopsy
  • Liver Biopsy
  • Lumpectomy
  • Lymph Node Biopsy
  • Lynch Syndrome Testing
  • Mammaprint Testing
  • Mammography
  • Mastectomy
  • Methylation Profiling
  • Modified Radical Mastectomy
  • Pathology Consultation
  • Preventive Medicine Counseling
  • Prophylactic Oophorectomy
  • Psa Testing
  • Radiation Therapy
  • Risk-Reducing Mastectomy
  • Risk-Reducing Salpingo-Oophorectomy
  • Selective Estrogen Receptor Modulator (SERM) Therapy
  • Sentinel Lymph Node Mapping
  • Targeted Genome Sequencing
  • Tumor Immunohistochemistry
  • Tumor Marker Testing
  • Ultrasound
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Practice locations

Distance from Change LocationEnter your Location

3800 Reservoir Rd NW
Lombardi Cancer Center
Washington, DC, 20007

202-444-2223

Fax 202-444-1229

Get Directions

miles away

Fax 202-444-1229

Insurance

MedStar Health accepts most major health insurance plans. If you are uncertain as to whether your individual health insurance plan is accepted at MedStar Health, please call your insurance company.

  • List of insurance plans we accept
    • Choice POS
    • IH-Open EPO Plus
    • IH-POS Plus
    • Coventry of Delaware HMO/PPO
    • Magellan Complete Care of VA - VA Medicaid MCO
    • DC/MD SHOP QHP Small Business Plans
    • IH-Open HMO
    • CareFirst FEP Blue Focus
    • Anthem BCBS of VA HealthKeepers Plus
    • Aetna Open Choice (PPO)
    • Kaiser Permanente Medicare Plus
    • Lasso Healthcare - Medicare Medical Savings Account
    • IH-Open POS Plus
    • Beech Street PPO
    • Kaiser Permanente Signature
    • Select HMO/HealthFund/Health Network
    • UnitedHealthcare Medicare Advantage DSNP District of Columbia
    • TRICARE for Life East
    • CareFirst MedStar PPO
    • UnitedHealthcare Medicare Adv. Special Needs Plans
    • IH-Indemnity
    • United Student Resources
    • CareFirst (NCA) Indemnity
    • Cigna Achieve Medicare (HMO C-SNP)
    • MedStar Family Choice DC Healthcare Alliance
    • Humana Medicare Advantage - HMO Open Access
    • IH-Network Only Plus
    • AMERIVANTAGE/Amerigroup Community Care
    • Anthem Federal Employee Program Basic
    • CareFirst Federal Employee Program (Std. & Basic PPO)
    • United Healthcare Choice Plus Cardiac Global
    • TriWest Healthcare Alliance
    • Amerigroup DC Healthy Families
    • Kaiser Permaenete Signature - Added Choice Cardiac Global
    • Johns Hopkins Advantage MD HMO
    • CareFirst Administrators
    • MultiPlan, Inc
    • Kaiser Permanente Flexible Choice POS Cardiac Global
    • Kaiser Permanente Medicare Advantage Signature and Select
    • IH-POS
    • Aetna Better Health of VA
    • Choice Fund PPO
    • First Health PPO
    • United Healthcare Choice Plus
    • UnitedHealthcare and AARP Medicare Complete Plans
    • Aetna Advantage 6350PD
    • Aetna Quality Point of Service (POS)
    • OCI Direct (HMO)
    • Medicare Direct
    • Tricare Reserve Select
    • United Healthcare Select HMO-EPO/NPP Cardiac Global
    • Medicare Advantage - Advantra Value (PPO)
    • Anthem BCBS Medi Blue SNP
    • BCBS of Michigan (BCN Advantage,Security Blue, Freedom, Medicare PLUS Blue Group PPO)
    • Aetna Traditional Choice (PPO)
    • CIGNA Indemnity
    • AmeriHealth Caritas DC Healthy Families
    • Aetna Basic
    • Aetna Medicare Advantage HMO & PPO Plans
    • CareFirst Blue Preferred PPO
    • Kaiser Permanente Select Cardiac Global
    • Network OA
    • Maryland Physicians Care MCO
    • HighMark
    • CareFirst Dual Prime HMO-SNP
    • United Healthcare Select HMO - EPO/NPP
    • Aetna Better Health of MD
    • Aetna Classic 3500
    • HumanaChoice Honor's plan PPO
    • Aetna Medicare Advantage PFFS Plan
    • Aetna Classic 5000PD
    • CIGNA PPO
    • Police and Fire Clinic
    • IH-HMO
    • CareFirst MedStar Select PPO
    • Humana Gold Plus HMO
    • Coventry Health Care of Virginia
    • Sentara Health
    • Healthy Blue (HMO, POS)
    • First Health PPO
    • UHC Group Medicare Advantage Plans (HMO, POS, PPO)
    • CareFirst BlueChoice HMO
    • Employee Health Plan
    • Kaiser Maryland Medicaid MCO
    • Humana Medicare Advantage - PPO
    • Aetna Advantage 6350
    • CareFirst Blue Choice Opt Out Plus Open Access (POS)
    • Uniformed Services Family Health Plan
    • Anthem BCBS Medi Blue Plus
    • CIGNA EPO
    • Cigna Alliance Medicare (HMO)
    • Optimum Choice Preferred (POS)
    • CareFirst Maryland Indemnity or PPO
    • CareFirst Group Medicare Advantage
    • United Healthcare Choice
    • Jai Medical Systems - Maryland Health Choice
    • CareFirst Blue Card Program
    • CareFirst NASCO
    • Navigate
    • MD IPA (HMO) & MD IPA Preferred Cardiac Global
    • POS OA
    • BCBS Out-of-State Medicare Plans (Blue Advantage)
    • United HealthCare Community Plan - Maryland Health Choice Program
    • Cigna TotalCare (HMO D-SNP)
    • Choice POS II
    • United Healthcare Navigate Cardiac Global
    • MedStar Family Choice - Maryland Health Choice
    • Aetna Elect Choice/ EPO (Aetna Health Fund)
    • Blue Choice Advantage
    • CareFirst BlueCross BlueShield Advantage Core/Enhanced
    • Choice Care Network/HUMANA (PPO)
    • OA Plus
    • Johns Hopkins Advantage MD PLUS PPO
    • Kaiser Permanente Select - Added Choice
    • Alterwood Advanatge HMO & DSNP Plans
    • United Healthcare Community Plan - VA Medicaid MCO
    • Veterans Affairs Community Care Network
    • Core Essential (HMO)
    • Aetna Signature Administrator PPO/TPA
    • Anthem BCBS of VA HealthKeepers (HMO)
    • IH-EPO Plus
    • IH-Open POS II
    • United Healthcare Options (PPO)
    • Options PPO Cardiac Global
    • CIGNA HMO Open Access
    • Fee-for-Service (FFS) District of Columbia, Maryland and Virginia Medicaid
    • CareFirst Group Medicare Advantage prescription drug benefit (PPO)
    • Kaiser Permanente Signature - Added Choice
    • Johns Hopkins Advantage MD PPO
    • WellPoint Maryland - Maryland Health Choice
    • Cigna True Choice Medicare (PPO)
    • CareFirst Blue Choice Opt Out Open Access
    • Aetna Worker's Compensation Network
    • NYC Medicare Advantage Plus
    • United Healthcare Select Plus (POS)
    • Aetna Managed Choice Open Access (POS)
    • Anthem BCBS of VA Key Care POS/PPO/Indemnity
    • Health Services for Children with Special Needs
    • CIGNA SureFit (HMO)
    • Aetna Elect Choice/ Open Access (POS)
    • HealthyBlue PPO
    • CIGNA POS/Network POS
    • Private Health Care Systems (PPO)
    • CareFirst Maryland Point of Service Plan
    • HumanaChoice PPO
    • IH-Open HMO Option
    • Aetna Premier 200PD
    • IH-Open Network Only Plus
    • Mamsi Life & Health (Indem./PPO)
    • Aetna Classic 5000
    • Cigna True Choice Plus Medicare (PPO)
    • TRICARE East Prime
    • Anthem Federal Employee Program Standard
    • Optima Family Care MCO - VA Medicaid MCO
    • IH-PPO
    • CIGNA HMO & Network (HMO)
    • M.D. IPA Preferred (POS)
    • Anthem BCBS Medi Blue Dual Adv
    • M.D. IPA (HMO)
    • Aetna HMO-Open Access/Select OA/HealthFund/Health Network Option OA
    • BlueChoice Open Access
    • UHC Passport
    • CIGNA Connect EPO
    • United Medicare Private Fee-for-Service (PFFS) plans
    • CIGNA PPO Plus
    • Aetna VA Exchange
    • Optimum Choice & Optimum Choice Preferred (POS) Cardiac Global
    • Aetna HMO
    • CareFirst Community Health Plan of MD
    • HUMANA/Choice Care Medicare Plans (Choice, Gold Choice)
    • Optimum Choice
    • Kaiser Permanente Select
    • Medicare FFS
    • Geisinger Medicare Advantage
    • Choice POS II Open Access
    • Priority Partners - Maryland Health Choice
    • Mamsi Life & Health (Indem./PPO) Cardiac Global
    • Advantra Platinum (PPO)
    • MedStar Family Choice DC Healthy Families
    • Anthem BCBS of VA HealthKeepers (POS & POS OA)
    • Great-West Healthcare POS/CIGNA
    • Coventry Health Care National Network PPO
    • Aetna Managed Choice (POS)
    • Aetna Student Health Insurance
    • TRICARE East Select
    • Aetna Advantage 5750
    • CareFirst EPO
    • Amerigroup DC Alliance
    • AmeriHealth Caritas DC Healthcare Alliance
    • Erickson Advantage Plans
    • Cigna Preferred Medicare (HMO)
    • UnitedHealthcare Individual Exchange Plans
    • United Healthcare Choice Cardiac Global
    • Private Fee-for-Service Plans (PFFS)
    • Kaiser Permanente Flexible Choice 3-tier POS
    • Kaiser Permanente HMO Plus and DHMO Plus Member

Videos

Education

Board Certification: American Board of Internal Medicine, Medical Oncology

Fellowship: Georgetown University School of Medicine GME (1993)

Fellowship: McGill University (1992)

Residency: McGill University Faculty of Medicine (1990)

Internship: Montreal General Hospital (1988)

Medical School: McGill University (1987)

Awards

  • Washingtonian Top Doc 2025 America’s Top Doctors for Women, Women’s Health Magazine
  • Marquis Who’s Who in America            
  • America’s Top Doctors, Castle Connolly
  • Newsweek’s Top Cancer Doctors
  • Top Doctors Washington DC, Washingtonian Magazine
  • Global Directory Top Doctors
  • Global Directory of Who’s Who
  • Top Doctors Washington DC Area, Northern Virginia Magazine
  • Estelle Ramey Mentorship Award, Georgetown University School of Medicine

Ratings and reviews

  • Explanations the care provider gave you about your problem or condition

    4.9
  • Extent to which the care provider listened to you

    4.9
  • Care provider’s discussion of any proposed treatment (options, risks, benefits, etc.)

    4.9
  • Provider included you in decisions

    4.9
  • Concern the care provider showed for your questions or worries

    4.9
  • Likelihood of recommending this care provider to others

    4.9
  • Sep 22, 2025

    Dr. Isaacs had been very understanding very patient and helpful.

  • Sep 16, 2025

    Dr. Isaacs is amazing. Her entire team is terrific. I have always, since first meeting Dr. Isaacs, had the best of care.

  • Sep 10, 2025

    Dr. Isaacs is the best oncologist imaginable.